Dear Colleague, We are delighted to announce the publication of Volume 7, Issue 4 of the Journal of Huntington’s Disease (JHD). This issue contains a selection of open acess content, including four research articles and one review article. The full contents of this issue can be accessed from the list below. Kind regards, Editors-in-Chief Blair R. Leavitt, MD, CM The University of British Columbia Vancouver, BC, Canada b.leavitt@iospress.com Leslie M. Thompson, PhD University of California, Irvine Irvine, CA, USA l.thompson@iospress.com | Click on links below to view more: Review Article Transcriptional Regulation of the Huntingtin Gene – Open Access Thomson, Sarah B. | Leavitt, Blair R. Research Articles Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability – Open Access Hashimoto, Makoto | Ho, Gilbert | Takamatsu, Yoshiki | Wada, Ryoko | Sugama, Shuei | Takenouchi, Takato | Masliah, Eliezer | Waragai, Masaaki Selective Neuronal Uptake and Distribution of AAVrh8, AAV9, and AAVrh10 in Sheep After Intra-Striatal Administration Mondo, Erica | Moser, Richard | Gao, Guangping | Mueller, Christian | Sena-Esteves, Miguel | Sapp, Ellen | Pfister, Edith | O’Connell, Denice | Takle, Kendra | Erger, Kirsten E. | Liu, Wanglin | Conlon, Thomas J. | DiFiglia, Marian | Gounis, Matthew J. | Aronin, Neil Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice – Open Access Morozko, Eva L. | Ochaba, Joseph | Hernandez, Sarah J. | Lau, Alice | Sanchez, Isabella | Orellana, Iliana | Kopan, Lexi | Crapser, Joshua | Duong, Janet H. | Overman, Julia | Yeung, Silvia | Steffan, Joan S. | Reidling, Jack | Thompson, Leslie M. Disease Progression in Huntington Disease: An Analysis of Multiple Longitudinal Outcomes Garcia, Tanya P. | Wang, Yuanjia | Shoulson, Ira | Paulsen, Jane S. | Marder, Karen Tetrabenazine Treatment Patterns and Outcomes for Chorea Associated with Huntington Disease: A Retrospective Chart Review Claassen, Daniel O. | Iyer, Ravi G. | Shah-Manek, Bijal | DiBonaventura, Marco | Abler, Victor | Sung, Victor W. Clinical Management of Neuropsychiatric Symptoms of Huntington Disease: Expert-Based Consensus Guidelines on Agitation, Anxiety, Apathy, Psychosis and Sleep Disorders – Open Access Anderson, Karen E. | van Duijn, Erik | Craufurd, David | Drazinic, Carolyn | Edmondson, Mary | Goodman, Nathan | van Kammen, Daniel | Loy, Clement | Priller, Josef | Goodman, LaVonne Veatch Huntington’s Disease and Employment: The Relative Contributions of Cognitive and Motor Decline to the Decision to Leave Work Watkins, Kristen | Purks, Jennifer | Kumar, Anagha | Sokas, Rosemary K. | Heller, Hope | Anderson, Karen E. Cognitive Performance After a One-Year Multidisciplinary Intensive Rehabilitation Program for Huntington’s Disease: An Observational Study – Open Access van Walsem, Marleen R. | Piira, Anu | Mikalsen, Geir | Fossmo, Hanne Ludt | Howe, Emilie I. | Knutsen, SynnØve F. | Frich, Jan C. Young People Living at Risk of Huntington’s Disease: The Lived Experience Lewit-Mendes, Miranda F. | Lowe, Georgia C. | Lewis, Sharon | Corben, Louise A. | Delatycki, Martin B. Other Content Upcoming Meetings Related to Huntington’s Disease – Openly Available | Most Read JHD Articles in November 2018 Listing articles published only in 2017 and 2018 so you can read the most popular recent content Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related – Open Access (Research Article in Vol.7, Iss.4, 2018) Hashimoto, Makoto | Ho, Gilbert | Takamatsu, Yoshiki | Wada, Ryoko | Sugama, Shuei | Takenouchi, Takato | Masliah, Eliezer | Waragai, Masaaki Physical Therapy and Exercise Interventions in Huntington’s Disease: A Mixed Methods Systematic Review – Open Access (Research Article in Vol.6, Iss.3, 2017) Fritz, Nora E. | Rao, Ashwini K. | Kegelmeyer, Deb | Kloos, Anne | Busse, Monica | Hartel, Lynda | Carrier, Judith | Quinn, Lori Clinical Management of Neuropsychiatric Symptoms of Huntington Disease: Expert-Based Consensus Guidelines on Agitation, Anxiety, Apathy, Psychosis and Sleep Disorders – Open Access (Research Article in Vol.7, Iss.4, 2018) Anderson, Karen E. | van Duijn, Erik | Craufurd, David | Drazinic, Carolyn | Edmondson, Mary | Goodman, Nathan | van Kammen, Daniel | Loy, Clement | Priller, Josef | Goodman, LaVonne Veatch A Fresh Look at Huntingtin mRNA Processing in Huntington’s Diseas – Open Access (Review Article in Vol.7, Iss.2, 2018) Romo, Lindsay | Mohn, Emily S. | Aronin, Neil Transcriptional Regulation of the Huntingtin Gene – Open Access (Review Article in Vol.7, Iss.4, 2018) Thomson, Sarah B. | Leavitt, Blair R. | CHDI Therapeutics Conference Feb 25–28, 2019 | Palm Springs, CA, USA CHDI announces that the 14th Annual HD Therapeutics Conference will be held February 25–28, 2019, in Palm Springs, CA, USA. The conference program is currently being crafted and will cover all aspects of drug discovery related to Huntington's disease. Sessions will include Neuronal Degeneration & Regenerative Medicine, HTT Lowering; Advanced Tools for HD, Translational Research, and more. Details are available via the CHDI Foundation website. | Sign Ups & Social Media Help Spread the News of JHD! | If you know of any colleagues or fellow researchers who are not yet signed up to receive the newsletter, we invite you to share this mailing with them. Click on the sign-up link at the bottom of this email or access here. JHD also has a social media presence! why not take the time today to follow us on Twitter and find us on Facebook? Be part of the discussion! | |