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COVID-19 Content Published in JAD

Bringing you direct access to the latest available research

The COVID-19 crisis is affecting many lives, and also research initiatives. IOS Press acknowledges the contributions of medical professionals, researchers, and first responders who are on the frontlines of the battle against the COVID-19 pandemic. We also appreciate the time and efforts of our editors, authors, and reviewers during this difficult time. All COVID-19 content published in IOS Press journals is openly available.

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Extract of COVID-19 Editorial by JAD's Editor-in-Chief

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In just a few months, COVID-19 (COVID) has transformed our lives: everything about work, education, and interpersonal relations is altered. Among all the changes, increased vulnerability of Alzheimer’s disease (AD) patients to death is one of the most striking. Up to 80% of those dying of COVID are in long-term care, translating to the possibility that over a third of mortality are those afflicted with AD, since approximately half of those in long-term care have AD. There are numerous reports as to why long-term care patients are particularly susceptible to COVID, with close cohabitation being a major factor. AD’s comorbidities further align with COVID’s risk factors: diabetes, heart disease, and minority status. Significantly, respiratory issues are common among most late-stage AD patients. The recent finding that risk of death from COVID shares the most important AD susceptibility gene, Apolipoprotein E4, also reinforces the link. All this calls out for careful study to determine the actual numbers of AD patients infected and dying of COVID.

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Full list of COVID-19 content at: iospress.com

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Most Read JAD COVID-19 Content in 2021

Top viewed articles via the IOS Press Content Library published in 2020 & 2021

Neurobiology of COVID-19
Fotuhi, Majid | Mian, Ali | Meysami, Somayeh | Raji, Cyrus A.

COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications
Yamamoto, Vicky | Bolanos, Joe F. | Fiallos, John | Strand, Susanne E. | Morris, Kevin | Shahrokhinia, Sanam | Cushing, Tim R. | Hopp, Lawrence | et al.

The Effects of Confinement on Neuropsychiatric Symptoms in Alzheimer’s Disease During the COVID-19 Crisis
Boutoleau-Bretonnière, Claire | Pouclet-Courtemanche, Hélene | Gillet, Aurelie | Bernard, Amelie | Deruet, Anne Laure | Gouraud, Ines | et al.

Alzheimer’s Disease and Face Masks in Times of COVID-19
Gil, Roger | Arroyo-Anlló, Eva M.

Potential Novel Role of COVID-19 in Alzheimer’s Disease and Preventative Mitigation Strategies
Naughton, Sean X. | Raval, Urdhva | Pasinetti, Giulio M.

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JAD COVID-19 Content Highlights* / Openly Available

EDITORIALS
Alzheimer’s Disease Patients in the Crosshairs of COVID-19
Perry, George

Summary: Calls for a study to determine the actual numbers of AD patients infected and dying of COVID-19. Knowledge of the extent and how to protect AD patients is imperative to this vulnerable population and their families. View

Dementia in the COVID-19 Period
Korczyn, Amos D.

Summary: Given the harsh prognosis once admitted to hospital, it may be better if people with cognitive impairment who develop COVID-19 remain at their residence and be treated there. View

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REVIEW ARTICLES
COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications
Yamamoto, Vicky | Bolanos, Joe F. | Fiallos, John | Strand, Susanne E. | Morris, Kevin | Shahrokhinia, Sanam | Cushing, Tim R. | Hopp, Lawrence | et al.

Summary: In this paper we have reviewed 28 vaccine clinical trials, several emerging diagnostic tools and therapeutics for COVID-19, which paints a promising picture for the management of this novel disease. There is a greater need to understand the importance of the transmission pathway of COVID-19 to inform the general population better and make practical guidelines to manage better and limit the spread. View

Neurobiology of COVID-19
Fotuhi, Majid | Mian, Ali | Meysami, Somayeh | Raji, Cyrus A.

Summary: We propose a basic “NeuroCovid” classification scheme that integrates concepts and highlights some of the short-term challenges for the practice of neurology today and the long-term sequalae of COVID-19 such as depression, OCD, insomnia, cognitive decline, accelerated aging, Parkinson’s disease, or Alzheimer’s disease in the future. View

Environmental Nanoparticles, SARS-CoV-2 Brain Involvement, and Potential Acceleration of Alzheimer’s and Parkinson’s Diseases in Young Urbanites Exposed to Air Pollution
Calderón-Garcidueñas, Lilian | Torres-Jardón, Ricardo | Franco-Lira, Maricela | Kulesza, Randy | González-Maciel, Angélica | Reynoso-Robles, Rafael | et al.

Alzheimer’s Disease and Face Masks in Times of COVID-19
Gil, Roger | Arroyo-Anlló, Eva M.

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RESEARCH ARTICLES
The Effects of Confinement on Neuropsychiatric Symptoms in Alzheimer’s Disease During the COVID-19 Crisis
Boutoleau-Bretonnière, Claire | Pouclet-Courtemanche, Hélene | Gillet, Aurelie | Bernard, Amelie | Deruet, Anne Laure | Gouraud, Ines | et al.

Summary: The first investigation of the effects of confinement during the COVID-19 crisis on neuropsychiatric symptoms in patients with AD. Critically, our study demonstrates how the confinement exacerbated neuropsychiatric symptoms in patients with low cognitive function in AD, whereas no such symptoms were induced in patients with more preserved cognition. View

Maximizing Safety in the Conduct of Alzheimer’s Disease Fluid Biomarker Research in the Era of COVID-19
Schindler, Suzanne E. | Jicha, Gregory A. | Nelson, Peter T. | Keene, C. Dirk | Blennow, Kaj | Molinuevo, José Luis | Masters, Colin L. | et al.

Summary: Since COVID-19 is likely to remain a threat for an extended period, the resumption of fluid biomarker studies requires the development and implementation of procedures that minimize the risk of in-person visits to participants, staff, and individuals handling the biofluid samples. View

Telemedicine for Delivery of Care in Frontotemporal Lobar Degeneration During COVID-19 Pandemic: Results from Southern Italy
Capozzo, Rosa | Zoccolella, Stefano | Frisullo, Maria Elisa | Barone, Roberta | Dell’Abate, Maria Teresa | Barulli, Maria Rosaria | Musio, Marco | et al.

Summary: The COVID-19 pandemic is changing clinical practice in neurology. Teleneurology is an effective tool for the remote evaluation of patients but its adoption for frontotemporal lobar dementia is in a preliminary stage. In this study, we evaluated multidisciplinary assessment of patients with FTD using telehealth. View

Resilience of Alzheimer’s Disease to COVID-19
Li, Jingwen | Long, Xi | Huang, Heqing | Tang, Jine | Zhu, Chunli | Hu, Shaoping | Wu, Jing | Li, Jinghong | Lin, Zhicheng | Xiong, Nian

Summary: Facing COVID-19, most vulnerable individuals are seniors, especially those with comorbidities. More attention needs to been paid to the COVID-19 patients with AD. We report for the first time a retrospective analysis of the clinical characteristics of AD patients with COVID-19 pneumonia. View

Managing Clinical Trials for Alzheimer’s Disease During the COVID-19 Crisis: Experience at Fundació ACE in Barcelona, Spain
Abdelnour, Carla | Esteban de Antonio, Ester | Pérez-Cordón, Alba | Lafuente, Asunción | Buendía, Mar | Pancho, Ana | Jofresa, Sara | et al.

Summary: The COVID-19 pandemic has brought great disruption to health systems worldwide. In response to this situation, some clinical and research centers have developed adaptation measures. The aim of this article is to describe the Fundació ACE Clinical Trials Strategic Plan developed to cope with COVID-19 outbreak and summarize its outcomes. View

Dementia Care in Times of COVID-19: Experience at Fundació ACE in Barcelona, Spain
Benaque, Alba | Gurruchaga, Miren Jone | Abdelnour, Carla | Hernández, Isabel | Cañabate, Pilar | Alegret, Montserrat | Rodríguez, Isabel | et al.

Summary: We have shown that Fundació ACE model of care has been able to successfully adapt to a health and social critical situation as COVID-19 pandemic. Overall, we were able to guarantee the continuity of care while preserving the safety of patients, families, and professionals. We also seized the opportunity to improve our model of care. View

Burnout of Healthcare Workers in Acute Care Geriatric Facilities During the COVID-19 Crisis: An Online-Based Study
El Haj, Mohamad | Allain, Philippe | Annweiler, Cédric | Boutoleau-Bretonnière, Claire | Chapelet, Guillaume | Gallouj, Karim | et al.

Cognitive Impairment Is a Common Comorbidity in Deceased COVID-19 Patients: A Hospital-Based Retrospective Cohort Study
Martín-Jiménez, Paloma | Muñoz-García, Mariana I. | Seoane, David | Roca-Rodríguez, Lucas | García-Reyne, Ana | Lalueza, Antonio | et al.

Death Rate Due to COVID-19 in Alzheimer’s Disease and Frontotemporal Dementia
Matias-Guiu, Jordi A. | Pytel, Vanesa | Matías-Guiu, Jorge

COVID-19 Crisis Effects on Caregiver Distress in Neurocognitive Disorder
Alexopoulos, Panagiotis | Soldatos, Rigas | Kontogianni, Evagellia | Frouda, Maria | loanna Aligianni, Souzana | Skondra, Maria | Passa, Maria | et al.

Implementing Delirium Prevention in the Era of COVID-19
Radhakrishnan, Nila S. | Mufti, Mariam | Ortiz, Daniel | Maye, Suzanne | Melara, Jennifer | Lim, Duke | Rosenberg, Eric I. | Price, Catherine C.

The Impact of Dementia on the Clinical Outcome of COVID-19: A Systematic Review and Meta-Analysis
Liu, Nanyang | Sun, Jiahui | Wang, Xiyuan | Zhao, Ming | Huang, Qianqian | Li, Hao

Effects of COVID-19 Home Confinement on Mental Health in Individuals with Increased Risk of Alzheimer’s Disease
Soldevila-Domenech, Natalia | Forcano, Laura | Boronat, Anna | Lorenzo, Thais | Piera, Iris | Puig-Pijoan, Albert | Mateus, Julian | González de Echevarri Gómez, José María | et al.

The Impact of a Global Pandemic on People Living with Dementia and Their Care Partners: Analysis of 417 Lived Experience Reports
Tam, Mallorie T. | Dosso, Jill A. | Robillard, Julie M.

Needs of Dementia Family Caregivers in Spain During the COVID-19 Pandemic
Carcavilla, Nuria | Pozo, Ana Sofía | González, Belén | Moral, Débora | Roldán, José Joaquín | Erice, Victoria | Remírez, Ana

COVID-19: Association Between Increase of Behavioral and Psychological Symptoms of Dementia During Lockdown and Caregivers’ Poor Mental Health
Pongan, Elodie | Dorey, Jean-Michel | Borg, Céline | Getenet, Jean Claude | Bachelet, Romain | Lourioux, Charles | Laurent, Bernard | Group COVCARE | Rey, Romain | Rouch, Isabelle

Neuropsychiatric Symptoms in Patients with Dementia Associated with Increased Psychological Distress in Caregivers During the COVID-19 Pandemic
Borelli, Wyllians Vendramini | Augustin, Marina Coutinho | de Oliveira, Paola Bell Felix | Reggiani, Lorenzo Casagrande | Bandeira-de-Mello, Renato G. | et al.

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ARTICLE COMMENTARIES
Awareness of the COVID-19 Outbreak and Resultant Depressive Tendencies in Patients with Severe Alzheimer’s Disease
Tsugawa, Akito | Sakurai, Shu | Inagawa, Yuta | Hirose, Daisuke | Kaneko, Yoshitsugu | Ogawa, Yusuke | Serisawa, Shuntaro | Takenoshita, Naoto | et al.

Summary: The ongoing coronavirus disease 2019 (COVID-19) pandemic has substantially affected patients with dementia and their caregivers. Our results indicate that for patients with moderate to severe cognitive impairment, it may be useful to prioritize prevention of their cognitive decline and maintenance of their functional independence, whereas for those with mild cognitive impairment, it may be useful to prioritize reducing psychological stress and preventing neuropsychiatric symptoms, such as depression. View

Dementia Care in the Time of COVID-19 Pandemic
Tousi, Babak

Summary: The concept of measuring activities during a pandemic in the early detection of a change in health status in the elderly is not new. Digital biomarkers are still in the early stage of validation to be used as the primary outcome. Design of future clinical trials may include digital biomarkers as outcome measures which should undergo the same formal regulatory process as traditional biomarkers for approval. View

Potential Novel Role of COVID-19 in Alzheimer’s Disease and Preventative Mitigation Strategies
Naughton, Sean X. | Raval, Urdhva | Pasinetti, Giulio M.

Summary: Type I interferon response plays an important role in both host response to viral infection, as well as AD pathology and may be a sensible therapeutic target in both AD and COVID-19. While the sum total effects of the COVID19 pandemic are not yet known it will undoubtedly affect many AD patients either directly or indirectly. View

Antivirals Against SARS-CoV2: Relevance to the Treatment of Alzheimer’s Disease
Naughton, Sean X. | Raval, Urdhva | Pasinetti, Giulio M.

Summary: Today, the number of deaths from COVID-19 worldwide is about 1 million. The number of people who suffer from AD is about 30 million worldwide, and there is strong evidence suggesting that at least half are caused by HSV1 in brain (in APOE ɛ4 carriers). This number is hugely greater than that of COVID-19 patients, and in AD, death follows what is often a long drawn-out almost death-like existence. View

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Discover more COVID-19 content at: iospress.com

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*This listing only highlights a small amount of COVID-19 content published in JAD.
To see a full list, go to the IOS Press website here.

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