Please feel free to forward to your colleagues and share the news of our journal | Dear Colleague, We are delighted to announce the publication of Volume 6, Issue 4 of Bladder Cancer (BLC). This issue hosts an outstanding selection of content, including two review articles, nine research articles and one systematic review. From the editors of the regular journal sections, there are also new Challenging Case, Clinical Trials Corner and Paper Alert contributions. In this issue, we are also pleased to include a Festchrift honoring the illustrious career of Bladder Cancer board member Prof. Margaret Anne Knowles on the occasion of her retirement. Comments co-Editor-in-Chief Seth P. Lerner: "Maggie, congratulations on a brilliant career. Your tireless work and devotion to doing science the right way has shone a brilliant light on the molecular underpinnings and biology of early stage bladder cancer that will serve as a beacon to all who carry on in this important field of translational research." The full issue is freely available online and can be browsed in full below. | As a member of our research community, we would like to invite you to contribute your own research articles to Bladder Cancer, which offers contributing authors many benefits: • First class Editorial Board • Rigorous peer review and speedy manuscript processing • Rapid online publication (pre-press) on acceptance • Articles are currently published Open Access with no article processing fee Submit your manuscript online via Editorial Manager View detailed Instructions to Authors Aims and Scope We look forward to working with you. Best wishes, Editors-in-Chief Seth P. Lerner, MD Scott Department of Urology Baylor College of Medicine Houston, Texas, USA Email: blc@iospress.com Dan Theodorescu, MD, PhD Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center Los Angeles, California, USA Email: blc@iospress.com | All content is currently freely available online to all readers Review Articles FGFR3 – a Central Player in Bladder Cancer Pathogenesis? Knowles, Margaret A. Diagnosis and Management of Checkpoint Inhibitor Side Effects in Patients with Bladder Cancer: the Urologist’s Perspective Shore, Neal Research Articles Etiology of Treatment Delays in Patients Receiving Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer El-Arabi, Ahmad M. | Alam, Syed M. | Sherman, Garth | Parker, William P. | Thompson, Jeffrey | Holzbeierlein, Jeffrey M. | Lee, Eugene K. | Wulff-Burchfield, Elizabeth M. 25-Year Trends in Stage-Specific Incidence Rates for Bladder Cancer in a Large Statewide Registry Loloi, Justin | Lin, Yu-Kuan | Camacho, Fabian | Lengerich, Eugene | Raman, Jay D. Outcomes of Trimodal Therapy for cT2-3 Urothelial Carcinoma in a Racially Diverse Population: A Single Institution Experience in the Bronx Gottlieb, Josh | Kovac, Evan | Aboumohamed, Ahmed | Schoenberg, Mark | Gartrell, Benjamin | Bodner, William | Guha, Chandan | Mehta, Keyur | Garg, Madhur | Sankin, Alexander Hyperthermia Improves Solubility of Intravesical Chemotherapeutic Agents Grimberg, Dominic C. | Shah, Ankeet | Tan, Wei Phin | Etienne, Wiguins | Spasojevic, Ivan | Inman, Brant A. Synthesis, Characterization, and Biological Activity of Anthraquinone-Substituted Imidazolium Salts for the Treatment of Bladder Cancer Stromyer, Michael L. | Weader, David J. | Satyal, Uttam | Abbosh, Philip H. | Youngs, Wiley J. 5α-Reductase Inhibitors Do Not Prevent the Development and Progression of Urothelial Cancer: In Vitro Evidence Nagata, Yujiro | Goto, Takuro | Jiang, Guiyang | Teramoto, Yuki | Miyamoto, Hiroshi Deciding When to Omit Repeat Transurethral Resection of Superficial Bladder Cancer: Do Photodynamic Diagnostics help? Sailer, Eva | Krause, Frens-Steffen | Tauber, Volkmar | Schimetta, Wolfgang | Alfred Graf, Sebastian Bladder Cancer Incidence and Survival in the United States and Texas Non-Latino Whites and Latinos Wu, Shenghui | Munoz, Edgar | Liu, Yanning | Svatek, Robert | Mansour, Ahmed M. | Ramirez, Amelie G. | Tomlinson, Gail | Mesa, Ruben A. | Rodriguez, Ronald | Michalek, Joel E. Identification of Sex Differences in Tumor-Specific T Cell Infiltration in Bladder Tumor-Bearing Mice Treated with BCG Immunotherapy Rousseau, Matthieu | O’Brien, Conan J.O. | Antequera, Eduardo | Zdimerova, Hana | Cansever, Dilay | Canton, Tracy | Zychlinsky Scharff, Anna | Ingersoll, Molly A. Systematic Review Adjuvant Treatment of Residual Disease Following Neoadjuvant Chemotherapy and Radical Cystectomy for Muscle Invasive Bladder Cancer Krebs, Markus | Sokolakis, Ioannis | Seiler, Roland | Daneshmand, Siamak | Grivas, Petros | Gakis, Georgios Other Content Festschrift in Honor of Professor Margaret Anne Knowles Zwarthoff, Ellen | Hurst, Carolyn Challenging Cases in Urothelial Cancer: Case 18 Soloway, Mark S. Clinical Trials Corner Issue 6(4) Agarwal, Piyush K. | Sternberg, Cora N. Paper Alert | Topical Instillations of Chemotherapy for Renal Pelvic Urothelial Cancer Messing, Edward M. | Listing articles published only in 2019 & 2020 so you can read the most popular recent content In the World of Bladder Tumors: Size Does Matter (Research Article in Vol.6, Iss.2, 2020) Loloi, Justin | Allen, Jordan L. | Schilling, Amber | Hollenbeak, Christopher | Merrill, Suzanne B. | Kaag, Matthew G. | Raman, Jay D. CIS of the Bladder: Significance and Implications for Therapy (Review Article in Vol.5, Iss.3, 2019) Mirabal, Jorge Rivera | Taylor, John A. | Lerner, Seth P. The Urinary Microbiome and Bladder Cancer: Susceptibility and Immune Responsiveness (Research Article in Vol.6, Iss.3, 2020) Andolfi, Ciro | Bloodworth, Jeffrey C. | Papachristos, Apostolos | Sweis, Randy F. Clinical Development of FGFR3 Inhibitors for the Treatment of Urothelial Cancer (Review Article in Vol.5, Iss.2, 2019) Ibrahim, Tony | Gizzi, Marco | Bahleda, Ratislav | Loriot, Yohann Histologic Variants of Urothelial Carcinoma: Morphology, Molecular Features and Clinical Implications (Review Article in Vol.6, Iss.2, 2020) Alderson, Meera | Grivas, Petros | Milowsky, Matthew I. | Wobker, Sara E. Cisplatin Ineligibility for Patients With Metastatic Urothelial Carcinoma: A Survey of Clinical Practice Perspectives Among US Oncologists (Research Article in Vol.5, Iss.4, 2019) Galsky, Matthew D. | Ma, Esprit | Shah-Manek, Bijal | Mills, Rosalina | Ha, Long | Krebsbach, Craig | Blouin, Eric | Tayama, Darren | Ogale, Sarika Systematic Review: Targeting HER2 in Bladder Cancer (Review Article in Vol.5, Iss.1, 2019) Koshkin, Vadim S. | O’Donnell, Peter | Yu, Evan Y. | Grivas, Petros Plasmacytoid Urothelial Carcinoma: Response to Chemotherapy and Oncologic Outcomes (Research Article in Vol.6, Iss.1, 2020) Diamantopoulos, Leonidas N. | Khaki, Ali Raza | Grivas, Petros | Gore, John L. | Schade, George R. | Hsieh, Andrew C. | Lee, John K. | Yezefski, Todd | Yu, Evan Y. | Schweizer, Michael T. | et al. | Think Tank 2020 Report Like many other events this year, the Bladder Cancer Advocacy Network's Think Tank meeting transitioned to an interactive virtual meeting that took place in August. More than 240 clinicians, researchers, and patient advocates from the US and six other countries, viewed presentations from leading bladder cancer experts. The 2020 Virtual Think Tank discussion on “BCG-Unresponsive Non-Muscle Invasive Bladder Cancer” was co-chaired by medical oncologist Peter Black, MD (Vancouver General Hospital) and urologist Colin Dinney, MD (University of Texas MD Anderson Cancer Center). The meeting was divided into a clinical panel and a translational panel, and a full report has been published online. Access the report in full via the BCAN website (Fall 2020 newsletter, p.9). The next Think Tank is planned as an in-person event in August 2021 in Denver, Colorado | Help Spread the News of BLC! | If you know of any colleagues or fellow researchers who are not yet signed up to receive the newsletter, we invite you to share this mailing with them. Click on the visual or access the sign-up link here. BLC has an active social media presence. 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